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COVER ARTICLE

SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease

Yichang Shao, Qingdian Mu, Rong Wang, Hongbin Luo, Zijun Song, Pengfei Wang, Jingshu Song, Chaodong Ge, Jiyan Zhang, Junxia Min, Fudi Wang

Science China Life Sciences 2025, 68(7): 1855-1870

PROFILE

Profile of Dr. Hang Sun

Science China Life Sciences 2025, 68(7): 1871-1872

RESEARCH PAPER

Decoupled responses of soil microbial diversity and ecosystem functions to successive degeneration processes in alpine pioneer community

Yazhou Zhang, J. Aaron Hogan, Yaojun Ye, Xin Liu, Minshu Song, Jianguo Chen, Hang Sun

Science China Life Sciences 2025, 68(7): 1873-1888

REVIEW

Toll-like receptor signaling in teleosts

Jianguo Su

Science China Life Sciences 2025, 68(7): 1889-1911

Clinical biomarkers of perioperative neurocognitive disorder: initiation and recommendation

Jianhui Liu, Cheng Li, Junyan Yao, Lei Zhang, Xuan Zhao, Xin Lv, Zhiqiang Liu, Changhong Miao, Yingwei Wang, Hong Jiang, Weifeng Yu, Tianlong Wang, Dongxin Wang, E Wang, Xiaoping Gu, Hailong Dong, Junli Cao, Yuan Shen, Weihong Song, Shengdi Chen, Yanjiang Wang, Guanghui Liu, Zhongcong Xie, Lize Xiong, Jialin C. Zheng

Science China Life Sciences 2025, 68(7): 1912-1940

The landscape of cell lineage tracing

Ye Feng, Guang Liu, Haiqing Li, Lin Cheng

Science China Life Sciences 2025, 68(7): 1941-1963

RESEARCH PAPER

Exposure to the prenatal enriched environment alters maternal gut microbiota and promotes embryonic neurodevelopment via activating the AHR-Src pathway

Yuhan Liu, Chenna Huang, Xuejun Cheng, Wenzheng Qu, Xueyi Wang, Suxiao Liu, Jinyu Zhang, Ying Li, Xiaoli Huang, Jinpiao Zhu, Daqing Ma, Qiang Shu, Xuekun Li

Science China Life Sciences 2025, 68(7): 1964-1979

Inhibition of recurrence and metastasis in triple-negative breast cancer through nanoparticle-mediated silencing of LPCAT1 to remodel ATP energy metabolism

Xiuling Li, Senlin Li, Haotian Li, Guo Wu, Huijie Zhao, Shaomin Liu, Xiaoding Xu, Phei Er Saw

Science China Life Sciences 2025, 68(7): 1980-1995

VPS35/Retromer-dependent MT1-MMP regulation confers melanoma metastasis

Qinggang Hao, Yan Bai, Ruiqi Guan, Rui Dong, Weiyu Bai, Hayam Hamdy, Liqiong Wang, Mingyao Meng, Yan Sun, Junling Shen, Jianwei Sun

Science China Life Sciences 2025, 68(7): 1996-2009

Downregulation of METTL3 enhances TRADD-mediated apoptosis in inflammatory bowel disease

Tingyue Gong, Zhiyang Zeng, Zurui Huang, Yang Luo, Xiya Cao, Hao Li, Yongheng Zhao, Dali Han, Dali Li, Ming Zhong

Science China Life Sciences 2025, 68(7): 2010-2027

Transient receptor potential vanilloid-1 (TRPV1) is a mediator of noise-induced neural damage in zebrafish and mice

Ruicun Liu, Boyu Luo, Honglu Yan, Qing Lin, Wei Liu, Xiaowei Hao, Shuai Huang, Zhenjun Luo, Tuoyu Liu, Jinyu Li, Zhiyuan Shi, Songzuo Liu, Qing Yuan, Yue Teng

Science China Life Sciences 2025, 68(7): 2028-2042

Glutaminolysis and α-ketoglutarate-stimulated KCa3.1 expression contribute to β-adrenoceptor activation-induced myocardial fibrosis in mice

Ru-Yue Bai, Lin-Hong Wu, Yan Wang, Chen Guo, Gang She, Zheng-Da Pang, Jing-Jing Li, Xin-Yi Zhao, Meng-Zhuan Han, Xia-Xia Hai, Yi-Yi Yang, Yi Zhang, Li-Mei Zhao, Lian-Ying Jiao, Xiao-Jun Du, Xiu-Ling Deng

Science China Life Sciences 2025, 68(7): 2043-2057

Maternal transcription factor OTX2 directly inducesSETD1Aand promotes embryonic genome activation in human pre-implantation embryos

Tianlei Zhang, Ziyan Peng, Fei Meng, Zhuo Li, Junru Chen, Qinwei Zhou, Lizhi Leng, Hao Bo, Guangxiu Lu, Yun Deng, Feng Gu, Ge Lin

Science China Life Sciences 2025, 68(7): 2058-2072

Structure-based principles underlying ligand recognition of xanthine-II riboswitch

Xiaochen Xu, Mengqi He, Xiaoqing Tai, Qianyu Ren, Xin Shen, Chunyan Li, Aiming Ren

Science China Life Sciences 2025, 68(7): 2073-2084

Evolutionary repeatability of chromatin accessibility in the hippocampus between echolocating bats and soft-furred tree mice

Luye Shi, Yuanshuo Ma, Qinyang Hua, Junjun Hao, Qin Zhang, Yaxin Ye, Lu Yang, Qi Liu, Peng Chen, Zhen Liu, Peng Shi

Science China Life Sciences 2025, 68(7): 2085-2093

Metabolome genome-wide association analyses identify a splice mutation inAADATaffects lysine degradation in duck skeletal muscle

Dapeng Liu, Wenlei Fan, Youyou Yang, Zhanbao Guo, Yaxi Xu, Jian Hu, Tong Liu, Simeng Yu, He Zhang, Jing Tang, Shuisheng Hou, Zhengkui Zhou

Science China Life Sciences 2025, 68(7): 2094-2105

Does caudate lobe resection really improve the surgical outcomes of patients with hilar cholangiocarcinoma? A multicenter retrospective study

Ran Tao, Tong Yuan, Qi Cheng, Deyu Li, Qiumeng Liu, Chang Shu, Chuang Peng, Yongjun Chen, Xiaoping Chen, Erlei Zhang, Shuai Xiang

Science China Life Sciences 2025, 68(7): 2106-2120

CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity

Huaqiang Yang, Xi Ji, Haiwen Zhong, Xiaohui Yang, Dandan Hu, Gengyuan Cai, Zhenfang Wu

Science China Life Sciences 2025, 68(7): 2121-2136

Bacterial population dynamics and biosafety assessment in a closed Bioregenerative Life Support System during the “Lunar Palace 365” experiment

Yuming Fu, Yueying Lu, Jianlou Yang, Hong Liu

Science China Life Sciences 2025, 68(7): 2137-2149

Weakened priming effect along soil profile in alpine grasslands on the Tibetan Plateau

Mei He, Kai Fang, Meng Tang, Xuehui Feng, Shuqi Qin, Leiyi Chen, Yuanhe Yang

Science China Life Sciences 2025, 68(7): 2150-2161

INSIGHT

The immuno-metabolic trade-off: a driver of metabolic disorders and aging

Juanhong Liu, Qinlei Huang, Feng Liu

Science China Life Sciences 2025, 68(7): 2162-2165

LETTER TO THE EDITOR

Exposure to zearalenone exacerbates the decrease in calcium transport via selective regulation to estrogen receptor α/β in estrogenic deficient model

Qingxiu Liu, Leli Wang, Yafei Liu, Shimeng Huang, Lihong Zhao, Yulong Yin, Qiugang Ma

Science China Life Sciences 2025, 68(7): 2166-2169

Disruption of the miR396 binding site inGROWTH-REGULATING FACTOR 4enhances grain size in wheat

Boshu Li, Xinwei Jiang, Zhuangzhuang Chai, Jinxing Liu, Caixia Gao, Kunling Chen

Science China Life Sciences 2025, 68(7): 2170-2172

Whole grain black rice: a paradigm shift from mainly calories to a nutritious food that benefits human health

Zenan Yang, Dianwei Li, Ruixue Wei, Xiaochi Zhao, Xingming Lian, Chao Ren, Jinghua Xiao, Yanhua Li, Xuan Chen, Rod A. Wing, Qifa Zhang, Hao Chen

Science China Life Sciences 2025, 68(7): 2173-2176

Lentiviral vectors for gene therapy of α-thalassemia

Saijuan Xu, Dan Liang, Yan Cheng, Gongrui Sun, Feiyan Zhao, Yang Yang, Haokun Zhang, Yongrong Lai, Bin Fu, Yuxuan Wu

Science China Life Sciences 2025, 68(7): 2177-2179

RESEARCH HIGHLIGHT

Understanding CoQ evolution in plants for crop trait design

Ya-Long Guo

Science China Life Sciences 2025, 68(7): 2180-2181

E3 ubiquitin ligases: swiss army knives for balancing immunity and flowering in plants

Zian Ye, Yonglin Wu, Mingjun Gao

Science China Life Sciences 2025, 68(7): 2182-2184

Two competing guilds as barometers of host health

Haohan Ma, Kai Wang, Changtao Jiang

Science China Life Sciences 2025, 68(7): 2185-2187

Attenuation of plant immune kinases by U-box type E3 ubiquitin ligases

Hui Tao, Yuese Ning, Feng He, Ruyi Wang

Science China Life Sciences 2025, 68(7): 2188-2190